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The innermembrane is adjacent to nuclear intermediate filaments that form the nuclear lamina, b. Once Tregs in aged individuals become IL-15dependent, there is a change in BIM expression that may be related to the phosphorylation ofthe molecule (Raynor 2013)

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Both thesemetabolites predominantly block NA reuptake.Few other TCAs also produce active metabolites.Inactivation occurs by oxidation and glucuronideconjugation. Taubert H, Bartel F, Greither T, Bache M, Kappler M, Kohler T, Bohnke A, Lautenschlager C,Schmidt H, Holzhausen H-J et al (2008) Association of HDM2 transcript levels with age ofonset and prognosis in soft tissue sarcomas. EPA, 2008),developed by the EPA and mainly containing data on pesti-cides, and the national Toxicology Program’s (nTP) data-base, which has information on a broader set of chemicals(nTP, 2011)

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